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EP 2 089 521 A1

(12)

(43) Date of publication: 19.08.2009 Bulletin 2009/34 (21) Application number: 07776571.7 (22) Date of filing: 01.05.2007

(51) International Patent Classification (IPC):  C12N 15/12(2006.01) C12N 15/11(2006.01) A61K 48/00(2006.01) A61P 29/00(2006.01) C07K 14/715(2006.01) A61K 38/17(2006.01) C07H 21/00(2006.01) (86) International application number: PCT/US2007/010556 (87) International publication number: WO 2008/051306 (02.05.2008 Gazette 2008/18)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 20.10.2006 US 862350 P 10.11.2006 WO PCT/US2006/000436 (71) Applicants: Ercole Biotech, Inc. Research Triangle Park, NC 27709 (US) The University of North Carolina At Chapel Hill Chapel Hill NC 27599-4105 (US)	(72) Inventors: SAZANI, Peter L. Chapel Hill, NC 27514 (US) GRAZIEWICZ, Maria Chapel Hill, NC 27514 (US) KOLE, Ryszard Chapel Hill, NC 27514 (US) (74) Representative: Peterreins, Frank  Fish & Richardson P.C. Highlight BusinessTowers Mies-van-der-Rohe-Strasse 8 80807 München 80807 München (DE)