(19)

(11)

EP 2 094 660 A2

(12)

(88) Date of publication A3: 22.01.2009 (43) Date of publication: 02.09.2009 Bulletin 2009/36 (21) Application number: 07819430.5 (22) Date of filing: 30.10.2007

(51) International Patent Classification (IPC):  C07D 213/42(2006.01) C07D 265/18(2006.01) A61K 31/513(2006.01) A61P 31/18(2006.01) C07D 239/10(2006.01) C07K 16/38(2006.01) A61K 31/536(2006.01) (86) International application number: PCT/EP2007/009389 (87) International publication number: WO 2008/052737 (08.05.2008 Gazette 2008/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 30.10.2006 US 863442 P 02.10.2007 US 865980 (71) Applicants: Roche Diagnostics GmbH 68305 Mannheim (DE) DE  F.HOFFMANN-LA ROCHE AG 4070 Basel (CH) AT BE BG CH CY CZ DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR	(72) Inventors: SIGLER, Gerald Carmel, IN 46032 (US) GHOSHAL, Mitali Fishers, IN 46038 (US) HUI, Raymond Indianapolis, IN 46220 (US) SORIANO, Glenda Indianapolis, IN 46220 (US)