(19)

(11)

EP 2 094 851 A2

(12)

(88) Date of publication A3: 04.12.2008 (43) Date of publication: 02.09.2009 Bulletin 2009/36 (21) Application number: 07868871.0 (22) Date of filing: 27.11.2007

(51) International Patent Classification (IPC):  C12N 15/52(2006.01) C12N 9/00(2006.01) C07C 327/36(2006.01) C12N 15/74(2006.01) C12P 7/40(2006.01) (86) International application number: PCT/US2007/085681 (87) International publication number: WO 2008/067338 (05.06.2008 Gazette 2008/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 27.11.2006 US 861117 P (71) Applicant: University of Maryland Biotechnology Institute Office of Research Admin/Tech. Dev. Baltimore, MD 21202 (US)	(72) Inventors: BELAS, Robert Catonsville, MD 21228 (US) GENG, Haifeng Baltimore, MD 21228 (US) (74) Representative: ABG Patentes, S.L.  Avenida de Burgos 16D Edificio Euromor 28036 Madrid 28036 Madrid (ES)