(19)

(11)

EP 2 097 390 A1

(12)

(43) Date of publication: 09.09.2009 Bulletin 2009/37 (21) Application number: 07824910.9 (22) Date of filing: 19.11.2007

(51) International Patent Classification (IPC):  C07D 239/84(2006.01) A61P 7/02(2006.01) A61K 31/517(2006.01) (86) International application number: PCT/GB2007/050698 (87) International publication number: WO 2008/065445 (05.06.2008 Gazette 2008/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 28.11.2006 GB 0623749 (71) Applicant: Shire LLC Florence, KY 41042 (US)	(72) Inventors: FRANKLIN, Richard Florence, Kentucky 41042 (US) GOLDING, Bernard Florence, Kentucky 41042 (US) (74) Representative: Harrison Goddard Foote  Belgrave Hall Belgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)