(19)

(11)

EP 2 097 454 A2

(12)

(88) Date of publication A3: 20.11.2008 (43) Date of publication: 09.09.2009 Bulletin 2009/37 (21) Application number: 07867237.5 (22) Date of filing: 16.10.2007

(51) International Patent Classification (IPC):  C07K 16/28(2006.01) C12N 15/11(2006.01) A61K 39/395(2006.01) G01N 33/68(2006.01) A61K 31/11(2006.01) C07K 14/705(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/US2007/022103 (87) International publication number: WO 2008/057171 (15.05.2008 Gazette 2008/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 16.10.2006 US 852022 P 11.05.2007 US 917561 P (71) Applicant: The Scripps Research Institute La Jolla, CA 92037 (US)	(72) Inventors: KANG, Young Jun San Diego, CA 92130 (US) HAN, Jiahuai San Diego, CA 92129 (US) (74) Representative: Fisher, Adrian John et al CARPMAELS & RANSFORD 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)