(19)

(11)

EP 2 099 439 A2

(12)

(88) Date of publication A3: 31.07.2008 (43) Date of publication: 16.09.2009 Bulletin 2009/38 (21) Application number: 07709271.6 (22) Date of filing: 06.02.2007

(51) International Patent Classification (IPC):  A61K 31/11(2006.01) A61K 31/275(2006.01) A61P 25/28(2006.01) A61P 25/16(2006.01) A61P 1/00(2006.01) A61P 9/10(2006.01) A61K 31/22(2006.01) A61P 19/02(2006.01) A61P 19/00(2006.01) A61P 11/00(2006.01) A61P 17/00(2006.01) A61P 37/06(2006.01) (86) International application number: PCT/PT2007/000009 (87) International publication number: WO 2008/069688 (12.06.2008 Gazette 2008/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR (30) Priority: 06.12.2006 US 873155 P (71) Applicant: ALFAMA - INVESTIGAÇÃO E DESENVOLVIMENTO DE PRODUTO 2781-901 Oeiras (PT)	(72) Inventors: ROMÃO, Carlos C. 2750 - 768 Cascais (PT) MATOS, Marta Norton De 1200-775 Lisboa (PT) (74) Representative: Paget, Hugh Charles Edward et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)