(19)

(11)

EP 2 099 491 A2

(12)

(88) Date of publication A3: 20.11.2008 (43) Date of publication: 16.09.2009 Bulletin 2009/38 (21) Application number: 07867620.2 (22) Date of filing: 05.12.2007

(51) International Patent Classification (IPC):  A61K 39/395(2006.01) C12N 5/06(2006.01) C12N 5/16(2006.01) G01N 33/53(2006.01) (86) International application number: PCT/US2007/024858 (87) International publication number: WO 2008/070090 (12.06.2008 Gazette 2008/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 05.12.2006 US 872792 P (71) Applicant: Oncomed Pharmaceuticals, Inc. Redwood City, CA 94053 (US)	(72) Inventors: LEWICKI, John Los Gatos, CA 95032 (US) GURNEY, Austin San Francisco, CA 94114 (US) SATYAL, Sanjeev San Carlos, CA 94070 (US) (74) Representative: King, Hilary Mary et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS London EC2V 8AS (GB)