(19)

(11)

EP 2 102 232 A2

(12)

(88) Date of publication A3: 09.10.2008 (43) Date of publication: 23.09.2009 Bulletin 2009/39 (21) Application number: 07855109.0 (22) Date of filing: 13.12.2007

(51) International Patent Classification (IPC):  C07K 14/435(2006.01) C12Q 1/48(2006.01) C12N 9/10(2006.01) (86) International application number: PCT/US2007/087334 (87) International publication number: WO 2008/079705 (03.07.2008 Gazette 2008/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 20.12.2006 US 870879 P (71) Applicant: Eli Lilly & Company Indianapolis, IN 46285 (US)	(72) Inventors: GUTIERREZ, Jesus Antonio Greenfield, IN 46228 (US) PERKINS, Douglas Raymond New Palestine, IN 46163 (US) SOLENBERG, Patricia Jean Indianapolis, IN 46256 (US) (74) Representative: Kent, Lindsey Ruth  Eli Lilly and Company Limited Lilly Research Center Erl Wood Manor Sunninghill Road Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)