(19)

(11)

EP 2 109 613 A2

(12)

(88) Date of publication A3: 24.04.2008 (43) Date of publication: 21.10.2009 Bulletin 2009/43 (21) Application number: 07759283.0 (22) Date of filing: 23.03.2007

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61P 25/20(2006.01) A61K 31/4985(2006.01) (86) International application number: PCT/US2007/064825 (87) International publication number: WO 2007/109799 (27.09.2007 Gazette 2007/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 23.03.2007 US 785959 P 08.02.2007 US 888866 P (71) Applicant: Teva Pharmaceutical Industries Ltd 49131 Petah Tiqva (IL)	(72) Inventors: MAINFELD, Alex Kfar-saba (IL) WIZEL, Shlomit 49742 Petah Tiqva (IL) MENDELOVICI, Marioara 76466 Rechovot (IL) LIBERMAN, Anita Tel-aviv (IL) KOLTAI, Tamas 42758, Netanya (IL) (74) Representative: Gallagher, Kirk James et al D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)