(19)

(11)

EP 2 109 767 A2

(12)

(88) Date of publication A3: 31.12.2008 (43) Date of publication: 21.10.2009 Bulletin 2009/43 (21) Application number: 07871092.8 (22) Date of filing: 21.09.2007

(51) International Patent Classification (IPC):  G01N 27/333(2006.01) G01N 21/77(2006.01) C07D 323/00(2006.01) (86) International application number: PCT/US2007/079248 (87) International publication number: WO 2008/076491 (26.06.2008 Gazette 2008/26)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 21.09.2006 US 826493 P (71) Applicant: Medtronic, Inc. 710 Medtronic Parkway NE Minneapolis, MN 55342-5604 (US)	(72) Inventors: ZHOU, Zhengrong Saint Paul, MN 55432-5604 (US) YE, Qingshan Plymouth, MN 55441 (US) (74) Representative: Golding, Louise Ann et al Frank B. Dehn & Co. St Bride's House 10 Salisbury Square London EC4Y 8JD London EC4Y 8JD (GB)