(19)

(11)

EP 2 112 990 A2

(12)

(88) Date of publication A3: 07.07.2005 (43) Date of publication: 04.11.2009 Bulletin 2009/45 (21) Application number: 04745200.8 (22) Date of filing: 06.07.2004

(51) International Patent Classification (IPC):  C07C 43/205(2006.01) (86) International application number: PCT/IT2004/000375 (87) International publication number: WO 2005/007603 (27.01.2005 Gazette 2005/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR Designated Extension States: AL HR LT LV MK (30) Priority: 18.07.2003 GB 0316910 (71) Applicant: SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 00144 Roma (IT)

(72) Inventors: GIANNINI, G., Sigma-Tau Ind. Farmac. Riunite Spa 00040 Pomezia (IT) MARZI, M., Sigma-Tau Ind. Farmac. Riunite Spa 00040 Pomezia (IT) ALLOATTI, Do., Sigma-Tau Ind. Farmac. Riunite Spa 00040 Pomezia (IT) TINTI, M. O., Sigma-Tau Ind. Farmac. Riunite Spa 00040 Pomezia (IT) RICCIONI, T., Sigma-Tau Ind. Farm. Riuniti S.p.a. 00040 Pomezia (IT) MARCELLINI, M., Sigma-Tau Ind. Farm. Riuniti Spa 00040 Pomezia (IT) (74) Representative: Spadaro, Marco et al Studio Associato LEONE & SPADARO Viale Europa, 15 00144 Roma 00144 Roma (IT)