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(11)

EP 2 114 394 A1

(12)

(43) Date of publication: 11.11.2009 Bulletin 2009/46 (21) Application number: 07867308.4 (22) Date of filing: 30.10.2007

(51) International Patent Classification (IPC):  A61K 31/275(2006.01) C07F 15/00(2006.01) A61K 31/382(2006.01) (86) International application number: PCT/US2007/022893 (87) International publication number: WO 2008/100301 (21.08.2008 Gazette 2008/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 14.02.2007 US 901190 P (71) Applicant: BIONUMERIK PHARMACEUTICALS, INC. San Antonio, Texas 78229 (US)	(72) Inventors: CHEN, Xinghai San Antonio, TX 78248 (US) PETLURU, Pavankumar, N.V. San Antonio, TX 78248 (US) HUANG, Qiuli San Antonio, TX 78230 (US) NARKUNAN, Kesavaram San Antonio, TX 78249 (US) HAUSHEER, Frederick, H. Boerne, TX 78015 (US) (74) Representative: Lucas, Brian Ronald  Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)