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(11)

EP 2 114 418 A1

(12)

(43) Date of publication: 11.11.2009 Bulletin 2009/46 (21) Application number: 08725393.6 (22) Date of filing: 08.02.2008

(51) International Patent Classification (IPC):  A61K 33/24(2006.01) A01N 55/02(2006.01) A61K 31/28(2006.01) (86) International application number: PCT/US2008/001752 (87) International publication number: WO 2008/097661 (14.08.2008 Gazette 2008/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 09.02.2007 US 889171 P 13.02.2007 US 889681 P (71) Applicants: Poniard Pharmaceuticals, Inc. Seattle WA 98119-4114 (US) Genzyme Corporation Cambridge, MA 02142 (US)	(72) Inventors: LEIGH, Alistair J. Seattle, WA 98103 (US) PROCYSHYN, Christopher A. Surrey, BC, V4A 8N1 (CA) WONG, Ernest, S., Y. Superior, CO 80027 (US) GIANDOMENICO, Christen, M. Blaine, WA 98230 (US) (74) Representative: Lucas, Brian Ronald  Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)