(19)
(11) EP 2 114 419 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
11.06.2014 Bulletin 2014/24

(45) Mention of the grant of the patent:
09.04.2014 Bulletin 2014/15

(21) Application number: 08714162.8

(22) Date of filing: 01.02.2008
(51) International Patent Classification (IPC): 
A61K 33/36(2006.01)
A61P 37/06(2006.01)
A61P 29/00(2006.01)
(86) International application number:
PCT/US2008/052751
(87) International publication number:
WO 2008/097824 (14.08.2008 Gazette 2008/33)

(54)

SODIUM META ARSENITE FOR USE IN THE TREATMENT OF PAIN AND INFLAMMATION

NATRIUM META-ARSENIT ZUR VERWENDUNG IN DER BEHANDLUNG VON SCHMERZEN UND ENTZÜNDUNGEN

MÉTA-ARSÉNITE DE SODIUM POUR L'UTILISATION DANS LE TRAITEMENT DE LA DOULEUR ET DES INFLAMMATIONS


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

(30) Priority: 02.02.2007 US 899007 P
31.01.2008 US 68006

(43) Date of publication of application:
11.11.2009 Bulletin 2009/46

(60) Divisional application:
14001283.2

(73) Proprietor: Panaphix, Inc.
Tenafly, NJ 07670 (US)

(72) Inventors:
  • HWANG, Michael
    Chappaqua, NY 10514 (US)
  • YANG, Yong-Jin
    Kyonggi-do 463-500 (KR)

(74) Representative: Müller-Boré & Partner Patentanwälte PartG mbB 
Friedenheimer Brücke 21
80639 München
80639 München (DE)


(56) References cited: : 
EP-A- 1 736 161
WO-A-03/090766
   
  • ISHII Y: "STUDIES ON RELATIONSHIP BETWEEN ARSENOUS OXIDE INDUCED ANALGESIA AND MONOAMINE LEVELS IN THE BRAIN OF A MOUSE" SHIKWA GAKUHO, vol. 86, no. 5, 1986, pages 713-731, XP009099577
  • ISHII Y; TSUTSUMI S: "RELATIONSHIPS BETWEEN DIARSENIC TRIOXIDE INDUCED ANALGESIA AND MONOAMINE IN MOUSE BRAIN" JAPANESE JOURNAL OF PHARMACOLOGY, vol. 36, no. Suppl., 1984, page 216P, XP009099578
  • GARCIA-CHAVEZ ET AL: "Lipid oxidative damage and distribution of inorganic arsenic and its metabolites in the rat nervous system after arsenite exposure: Influence of alpha tocopherol supplementation" NEUROTOXICOLOGY, TOX PRESS, RADFIELD, AR, IN, vol. 27, no. 6, 5 December 2006 (2006-12-05), pages 1024-1031, XP005792766 ISSN: 0161-813X
  • VAHIDNIA A; ROMIJN F; TILLER M; VAN DER VOET G B; DE WOLFF F A: "Arsenic-induced toxicity: effect on protein composition in sciatic nerve" HUMAN & EXPERIMENTAL TOXICOLOGY, vol. 25, no. 11, November 2006 (2006-11), pages 667-674, XP002479000
  • MAVROMATIS BLANCHE H; KESSLER CRAIG M; CHESON BRUCE D; SEIN AUNG; SHARP STEWART A: "The impact of GM-CSF on arsenic trioxide (As2O3, trisenox) therapy in patients with myelodysplastic syndrome (MDS): Preliminary results of a phase II study" BLOOD, vol. 108, no. 11(2), 16 November 2006 (2006-11-16), page 299B, XP009099580
  • KIM KEVIN B; BEDIKIAN AGOP Y; CAMACHO LUIS H; PAPADOPOULOS NICHOLAS E; MCCULLOUGH CECILIA: "A phase II trial of arsenic trioxide in patients with metastatic melanoma" CANCER, vol. 104, no. 8, 15 October 2005 (2005-10-15), pages 1687-1692, XP002479001
  • AU WING Y; LO RICO K H; CHOW CHIT; KUMANA CYRUS R; SRIVASTAVA GOPESH; LIANG RAYMOND H; KWONG YOK-LAM: "In vitro and in vivo activity of arsenic trioxide in non-Hodgkin lymphoma" PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 47, April 2006 (2006-04), XP001538423
  • YIN K, ZHOU L: "Experimental study on the therapeutic mechanism of arsenic trioxide (As2O3) for bronchial asthma" JIANGSU YIYAO, vol. 28, no. 9, 2002, pages 662-665, XP001538668
  • YAO X, SUN P, HUANG M, ZHU CH, YIN K: "Molecular mechanism of arsenic trioxide in preventing and treating airway inflammation of asthma: effects of arsenic trioxide on the gene expression of mitogen-activated protein kinase phosphatase" ZHONGGUO LINCHUANG KANGFU, vol. 8, no. 30, 2004, pages 6652-6653, XP001538669
  • ZHOU LIN-FU ET AL: "[Effect of arsenic trioxide on apoptosis of pulmonary eosinophile in asthmatic guinea-pigs]" MEDLINE,, 1 January 1900 (1900-01-01), XP002405729
  • TAMURA A: "Studies on anti-inflammatory effect of arsenic, especially on anti-edematous effect" SHIKA GAKUHO - JOURNAL OF TOKYO DENTAL COLLEGE SOCIETY, TOKYO SHIKA DAIGAKU GAKKAI,TOKYO, JP, vol. 81, no. 3, 1 March 1981 (1981-03-01), pages 511-531, XP009110877 ISSN: 0037-3710
  • LI L, ZENG J, CHEN Y, ZHOU Z: "Therapeutic effect of sodium arsenite on rheumatoid arthritis in rats" ZHONGGUO BINGLI SHENGLI ZAZHI, vol. 23, no. 2, 1 January 2007 (2007-01-01), pages 348-351, XP001538670
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).