(19)
(11) EP 2 114 919 A2

(12)

(88) Date of publication A3:
29.01.2009

(43) Date of publication:
11.11.2009 Bulletin 2009/46

(21) Application number: 08708540.3

(22) Date of filing: 31.01.2008
(51) International Patent Classification (IPC): 
C07D 401/12(2006.01)
(86) International application number:
PCT/EP2008/051230
(87) International publication number:
WO 2008/092939 (07.08.2008 Gazette 2008/32)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA MK RS

(30) Priority: 31.01.2007 SI 200700024
28.03.2007 SI 200700078
10.10.2007 EP 07019823

(71) Applicant: Krka Tovarna Zdravil, D.D., Novo Mesto
8501 Novo Mesto (SI)

(72) Inventors:
  • PLAPER, Igor
    8220 Smarjeske Toplice (SI)
  • PECAVAR, Anica
    8000 Novo Mesto (SI)
  • KOTAR-JORDAN, Berta
    8311 Kostanjevica na Krki (SI)
  • ZAJC, Natalija
    8340 Crnomelj (SI)
  • VRBINC, Miha
    8000 Novo Mesto (SI)
  • KOCEVAR, Anton
    8331 Suhor (SI)
  • PELKO, Mitja
    8000 Novo Mesto (SI)
  • VEVERKA,Miroslav
    847 08 Bratislava (SK)
  • VEVERKOVÁ, Eva
    847 08 Bratislava (SK)
  • SMODIS, Janez
    8000 Novo Mesto (SI)
  • ZUPET, Rok
    1211 Ljubljana (SI)

(74) Representative: UEXKÜLL & STOLBERG 
Patentanwälte Beselerstrasse 4
22607 Hamburg
22607 Hamburg (DE)

   


(54) PROCESS FOR THE PREPARATION OF OPTICALLY PURE OMEPRAZOLE VIA SALT FORMATION WITH A CHIRAL AMINE OR TREATMENT WITH AN ENTIOMER CONVERTING ENZYME AND CHROMATOGRAPHIC SEPERATION