(19)
(11) EP 2 114 983 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
18.02.2015 Bulletin 2015/08

(45) Mention of the grant of the patent:
17.12.2014 Bulletin 2014/51

(21) Application number: 08729313.0

(22) Date of filing: 07.02.2008
(51) International Patent Classification (IPC): 
C12N 9/12(2006.01)
(86) International application number:
PCT/US2008/053337
(87) International publication number:
WO 2008/098139 (14.08.2008 Gazette 2008/33)

(54)

AXL TYROSINE KINASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME

AXL-TYROSINKINASEHEMMER SOWIE VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNG

INHIBITEURS DES RECEPTEURS AXL A ACTIVITE TYROSINE KINASE ET PROCEDES DE FABRICATION ET D'UTILISATION DE CEUX-CI

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated Extension States:
AL BA MK RS

(30) Priority: 07.02.2007 US 888741 P

(43) Date of publication of application:
11.11.2009 Bulletin 2009/46

(73) Proprietor: The Regents of the University of Colorado, A Body Corporate
Denver, CO 80203 (US)

(72) Inventors:
  • GRAHAM, Douglas, Kim
    Aurora, CO 80016 (US)
  • SATHER, Susan, Louise
    Denver, CO 80209 (US)

(74) Representative: Exell, Jonathan Mark et al
Williams Powell Staple Court 11 Staple Inn Buildings
London WC1V 7QH
London WC1V 7QH (GB)


(56) References cited: : 
US-A1- 2004 157 774
   
  • YANAGITA MOTOKO ET AL: "Gas6 regulates mesangial cell proliferation through axl in experimental glomerulonephritis" AMERICAN JOURNAL OF PATHOLOGY, AMERICAN SOCIETY FOR INVESTIGATIVE PATHOLOGY, US, vol. 158, no. 4, 1 April 2001 (2001-04-01) , pages 1423-1432, XP002579911 ISSN: 0002-9440
  • SHANKAR SAI LATHA ET AL: "Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis" JOURNAL OF NEUROSCIENCE, THE SOCIETY, WASHINGTON, DC, US LNKD- DOI:10.1523/JNEUROSCI.5063-05.2006, vol. 26, no. 21, 24 May 2006 (2006-05-24), pages 5638-5648, XP002505665 ISSN: 1529-2401
  • GRAHAM DOUGLAS K ET AL: "A soluble truncated form of the Mer tyrosine kinase inhibits Gas6 activity in platelets and monocytes" BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, [Online] vol. 104, no. 11, part 1, 4 December 2004 (2004-12-04), page 436A, XP008102282 ISSN: 0006-4971 Retrieved from the Internet: URL:http://www.bloodjournal.org/> [retrieved on 2004-12-04]
  • SATHER SUSAN ET AL: "A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation" BLOOD, vol. 109, no. 3, 1 February 2007 (2007-02-01), pages 1026-1033, XP002607364 ISSN: 0006-4971
  • O'BRYAN J P ET AL: "AXL A TRANSFORMING GENE ISOLATED FROM PRIMARY HUMAN MYELOID LEUKEMIA CELLS ENCODES A NOVEL RECEPTOR TYROSINE KINASE" MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 11, no. 10, 1 January 1991 (1991-01-01), pages 5016-5031, XP009018736 ISSN: 0270-7306
  • STENHOFF J ET AL: "Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts" BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US LNKD- DOI:10.1016/J.BBRC.2004.05.070, vol. 319, no. 3, 2 July 2004 (2004-07-02), pages 871-878, XP004512520 ISSN: 0006-291X
  • CHEN C. ET AL.: 'Mer receptor tyrosine kinase signaling participates, in platelet function' ARTERIOSCLEROSIS THROMB. VASC. BIOL. vol. 24, 2004, pages 1118 - 1123, XP008116000
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).