(19)
(11) EP 2 114 996 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
10.06.2015 Bulletin 2015/24

(45) Mention of the grant of the patent:
06.05.2015 Bulletin 2015/19

(21) Application number: 08709295.3

(22) Date of filing: 29.01.2008
(51) International Patent Classification (IPC): 
G01N 33/68(2006.01)
 C07K 16/18(2006.01)
(86) International application number:
PCT/FI2008/050026
(87) International publication number:
WO 2008/092992 (07.08.2008 Gazette 2008/32)

(54)

METHOD FOR PREPARING HYPOALLERGENS

VERFAHREN ZUR HERSTELLUNG VON HYPOALLERGENEN

PROCÉDÉ DE PRÉPARATION D'HYPOALLERGÈNES

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

(30) Priority: 29.01.2007 FI 20075059
02.02.2007 US 887862 P

(43) Date of publication of application:
11.11.2009 Bulletin 2009/46

(73) Proprietor: Desentum Oy
02940 Espoo (FI)

(72) Inventors:
  • JYLHÄ, Sirpa
    FI-02210 Espoo (FI)
  • NIEMI, Merja
    FI-80130 Joensuu (FI)
  • ROUVINEN, Juha
    FI-80140 Joensuu (FI)
  • LAUKKANEN, Marja-Leena
    FI-02210 Espoo (FI)
  • TAKKINEN, Kristiina
    FI-02200 Espoo (FI)
  • SÖDERLUND, Hans
    FI-02940 Espoo (FI)
  • MÄKINEN-KILJUNEN, Soili
    FI-00710 Helsinki (FI)
  • HAAHTELA, Tari
    FI-00200 Helsinki (FI)

(74) Representative: Matilainen, Mirja Helena et al
Oy Jalo Ant-Wuorinen AB, Iso Roobertinkatu 4-6 A
00120 Helsinki
00120 Helsinki (FI)


(56) References cited: : 
EP-A1- 1 512 695
WO-A1-2012/143374
JP-A- 08 070 866
 WO-A1-2006/026994
WO-A2-2006/125201
   
  • SIEW LEONG CHAN ET AL: "Nuclear magnetic resonance structure-based epitope mapping and modulation of dust mite group 13 allergen as a hypoallergen", THE JOURNAL OF IMMUNOLOGY, vol. 176, 15 April 2006 (2006-04-15), pages 4852-4860, XP55023085,
  • AMIT A G ET AL: "Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 233, no. 4765, 1 January 1986 (1986-01-01), pages 747-753, XP009093965, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.2426778
  • FEDEROV ALEXANDER A ET AL: "The molecular basis for allergen cross-reactivity: Crystal structure and IgE-epitope mapping of birch pollen profilin", STRUCTURE, CURRENT BIOLOGY LTD., PHILADELPHIA, PA, US, vol. 5, no. 1, 15 January 1997 (1997-01-15), pages 33-45, XP002506728, ISSN: 0969-2126, DOI: 10.1016/S0969-2126(97)00164-0 [retrieved on 2004-06-05]
  • SPANGFORT M.D. ET AL.: 'Dominating IgE-Binding Epitope of Bet v 1, the Major Allergen of Birch Pollen, Characterized by X-ray Crystallography and Site-Directed Mutagenesis' THE JOURNAL OF IMMUNOLOGY vol. 171, 2003, pages 3084 - 3090, XP002448849 & DATABASE BIOSIS [Online] Database accession no. (PREV200300542484)
  • SWOBODA I. ET AL.: 'Mutants of the major ryegrass pollen allergen, Lol p 5, with reduced IgE-binding capacity: candidates for grass pollen-specific immunotherapy' EUR. J. IMMUNOL. vol. 32, 2002, pages 270 - 280, XP002377125 & DATABASE BIOSIS [Online] Database accession no. (PREV200200153340)
  • VENIEN A. ET AL.: 'Production and Epitopic Characterization of Monoclonal Antibodies Against Bovine Beta-Lactoglobulin' J. DAIRY SCI. vol. 80, 1997, pages 1977 - 1987, XP002485701 & DATABASE BIOSIS [Online] Database accession no. (PREV199799752059)
  • CLEMENT G. ET AL.: 'Epitopic characterization of native bovine Beta-lactoglobulin' JOURNAL OF IMMUNOLOGICAL METHODS vol. 266, 2002, pages 67 - 78, XP004372272 & DATABASE BIOSIS [Online] Database accession no. (PREV200200512245)
  • CHO Y. ET AL.: 'Probing the Retinol-binding Site of Bovine Beta-Lactoglobulin' THE JOURNAL OF BIOLOGICAL CHEMISTRY vol. 269, no. 15, 1994, XP003023024 & DATABASE BIOSIS [Online] Database accession no. (PREV199497279244)
  • LAVER W.G. ET AL.: 'Epitopes on Protein Antigens: Misconceptions and Realities' CELL vol. 61, 1990, XP003023025 & DATABASE BIOSIS [Online] Database accession no. (PREV199039024409)
  • LAUKKANEN M.-L. ET AL.: 'Hevein-specific recombinant IgE antibodies from huma single-chain antibody phage display libraries' JOURNAL OF IMMUNOLOGICAL METHODS vol. 278, 2003, pages 271 - 281, XP004453182 & DATABASE BIOSIS [Online] Database accession no. (PREV200300544168)
  • DATABASE GENESEQ [Online] XP003023026 Database accession no. (AAO31139) & WO 03 054216 A2
  • DATABASE GENESEQ [Online] XP003023027 Database accession no. (ADG38991) & US 2003 207336 A1
  • NIEMI M. ET AL.: 'Molecular Interactions between a Recombinant IgE Antibody and the Beta-Lactoglobulin Allergen' STRUCTURE vol. 15, November 2007, XP022336793 & DATABASE BIOSIS [Online] Database accession no. (PREV200800049795)
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).