(19)

(11)

EP 2 115 122 A2

(12)

(88) Date of publication A3: 11.12.2008 (43) Date of publication: 11.11.2009 Bulletin 2009/46 (21) Application number: 08724561.9 (22) Date of filing: 17.01.2008

(51) International Patent Classification (IPC):  C12N 5/00(2006.01) G01N 33/53(2006.01) C07K 14/00(2006.01) G01N 33/567(2006.01) (86) International application number: PCT/US2008/000595 (87) International publication number: WO 2008/088837 (24.07.2008 Gazette 2008/30)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 17.01.2007 US 880838 P (71) Applicant: The Board of Regents of the University of Oklahoma Norman, OK 73019 (US)	(72) Inventor: HILDEBRAND, William, H. Edmond, OK 73034 (US) (74) Representative: Hallybone, Huw George et al Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)