(19)
(11) EP 2 115 139 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
18.03.2015 Bulletin 2015/12

(45) Mention of the grant of the patent:
28.01.2015 Bulletin 2015/05

(21) Application number: 08709296.1

(22) Date of filing: 29.01.2008
(51) International Patent Classification (IPC): 
C12N 15/13(2006.01)
C07K 16/40(2006.01)
C07K 16/28(2006.01)
C40B 50/00(2006.01)
(86) International application number:
PCT/FI2008/050027
(87) International publication number:
WO 2008/092993 (07.08.2008 Gazette 2008/32)

(54)

METHOD FOR PRODUCING NOVEL IGE BASED REAGENTS

VERFAHREN ZUR HERSTELLUNG NEUER REAGENTIEN AUF IGE-BASIS

PROCEDE DE FABRICATION DE NOUVEAUX REACTIFS A BASE D'IGE


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

(30) Priority: 29.01.2007 FI 20075059
02.02.2007 US 887862 P
05.10.2007 FI 20075707
05.10.2007 US 977881 P

(43) Date of publication of application:
11.11.2009 Bulletin 2009/46

(73) Proprietor: Teknologian tutkimuskeskus VTT Oy
02044 VTT (FI)

(72) Inventors:
  • TAKKINEN, Kristiina
    FI-02200 Espoo (FI)
  • ROUVINEN, Juha
    FI-80140 Joensuu (FI)
  • NIEMI, Merja
    FI-80130 Joensuu (FI)
  • JYLHÄ, Sirpa
    FI-02210 Espoo (FI)
  • LAUKKANEN, Marja-Leena
    FI-02210 Espoo (FI)
  • SÖDERLUND, Hans
    FI-02940 Espoo (FI)

(74) Representative: Matilainen, Mirja Helena et al
Oy Jalo Ant-Wuorinen AB, Iso Roobertinkatu 4-6 A
00120 Helsinki
00120 Helsinki (FI)


(56) References cited: : 
EP-A1- 0 499 112
WO-A1-99/62550
US-A- 5 965 709
WO-A1-97/04807
WO-A2-2004/045512
US-A- 6 063 621
   
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  • JAKOBSEN CHARLOTTE G ET AL: "Isolation of high-affinity human IgE and IgG antibodies recognising Bet v 1 and Humicola lanuginosa lipase from combinatorial phage libraries.", MOLECULAR IMMUNOLOGY AUG 2004 LNKD- PUBMED:15302157, vol. 41, no. 10, August 2004 (2004-08), pages 941-953, XP002620240, ISSN: 0161-5890
  • LAUKKANEN MARJA-LEENA ET AL: "Hevein-specific recombinant IgE antibodies from human single-chain antibody phage display libraries.", JOURNAL OF IMMUNOLOGICAL METHODS JUL 2003 LNKD- PUBMED:12957414, vol. 278, no. 1-2, July 2003 (2003-07), pages 271-281, XP002620241, ISSN: 0022-1759
  • DE GENST ERWIN ET AL: "Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 21 MAR 2006 LNKD- PUBMED:16537393, vol. 103, no. 12, 21 March 2006 (2006-03-21), pages 4586-4591, XP002620494, ISSN: 0027-8424
  • NIEMI MERJA ET AL: "Molecular interactions between a recombinant IgE antibody and the beta-lactoglobulin allergen.", STRUCTURE (LONDON, ENGLAND : 1993) NOV 2007 LNKD- PUBMED:17997967, vol. 15, no. 11, November 2007 (2007-11), pages 1413-1421, XP002620242, ISSN: 0969-2126
  • SCHEFFER G.L. ET AL.: 'Specific detection of multidrug resistance MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies' CANCER RESEARCH vol. 60, 15 September 2000, pages 5269 - 5277, XP002249637
  • BINYAMIN L. ET AL.: 'Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody' INT. J. CANCER vol. 110, 2004, pages 882 - 890, XP003023005
  • STEINBERGER P. ET AL.: 'Construction of a combinatorial IgE library from an allergic patient' THE JOURNAL OF BIOLOGICAL CHEMISTRY vol. 271, no. 18, 03 May 1996, pages 10967 - 10972, XP002950279
  • HOOGENBOOM H.R.: 'Selecting and screening recombinant antibody libraries' NATURE BIOTECHNOLOGY vol. 23, no. 9, September 2005, pages 1105 - 1116, XP002348401
  • GERK P.M. ET AL.: 'Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide' DRUG METABOLISM AND DISPOSITION vol. 32, no. 10, 2004, pages 1139 - 1145, XP003023006
  • BORST P. ET AL.: 'MRP2 and 3 in health and disease' CANCER LETTERS vol. 234, 2006, pages 51 - 61, XP005324059
   
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