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(11)

EP 2 117 526 A2

(12)

(88) Date of publication A3: 24.07.2008 (43) Date of publication: 18.11.2009 Bulletin 2009/47 (21) Application number: 07854765.0 (22) Date of filing: 26.11.2007

(51) International Patent Classification (IPC):  A61K 31/17(2006.01) A61P 1/16(2006.01) C07C 229/40(2006.01) A61P 3/00(2006.01) (86) International application number: PCT/US2007/085543 (87) International publication number: WO 2008/067257 (05.06.2008 Gazette 2008/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR Designated Extension States: AL BA HR MK RS (30) Priority: 29.11.2006 US 867695 P (71) Applicant: Abbott Laboratories Abbott Park, IL 60064 (US)

(72) Inventors: SOUERS, Andrew J. Evanston, Illinois 60202 (US) GAO, Ju Gurnee, Illinois 60031 (US) HANSEN, Todd Matthew Grayslake, Illinois 60030 (US) IYENGAR, Rajesh R. Lindenhurst, Illinois 60046 (US) KYM, Philip R. Libertyville, Illinois 60048 (US) LIU, Bo X Waukegan, Illinois 60085 (US) PEI, Zhonghua Libertyvill, Illinois 60048 (US) YEH, Vince Chicago, Illinois 60640 (US) ZHAO, Gang Northbrook, Illinois 60062 (US) XIN, Zhili Lexington, MA 02420 (US) (74) Representative: Modiano, Micaela Nadia et al Modiano Josif Pisanty & Staub Ltd Thierschstrasse 11 80538 München 80538 München (DE)