(19)

(11)

EP 2 118 124 A1

(12)

(43) Date of publication: 18.11.2009 Bulletin 2009/47 (21) Application number: 07869957.6 (22) Date of filing: 27.12.2007

(51) International Patent Classification (IPC):  C07K 14/00(2006.01) (86) International application number: PCT/US2007/088910 (87) International publication number: WO 2008/083203 (10.07.2008 Gazette 2008/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 28.12.2006 US 882287 P (71) Applicant: Saint Louis University Saint Louis MO 63104 (US)	(72) Inventors: FAN, Xiaofeng St. Louis, MO 63104 (US) DI BISCEGLIE, Adrian, M. St. Louis, MO 63104 (US) (74) Representative: Dehmel, Albrecht  Dehmel & Bettenhausen Patentanwälte Herzogspitalstrasse 11 80331 München 80331 München (DE)