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EP 2 121 648 A2

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(88) Date of publication A3: 27.03.2008 (43) Date of publication: 25.11.2009 Bulletin 2009/48 (21) Application number: 07753654.8 (22) Date of filing: 21.03.2007

(51) International Patent Classification (IPC):  C07D 307/81(2006.01) C07D 405/04(2006.01) C07D 409/10(2006.01) C07D 413/10(2006.01) C07D 417/10(2006.01) C07D 491/04(2006.01) C07D 405/10(2006.01) C07D 405/14(2006.01) C07D 409/14(2006.01) C07D 417/04(2006.01) C07D 471/04(2006.01) (86) International application number: PCT/US2007/007044 (87) International publication number: WO 2007/109334 (27.09.2007 Gazette 2007/39)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (71) Applicant: EPIX Pharmaceuticals, Inc. Lexington, MA 02421 (US)

(72) Inventors: SAHA, Ashis Stow, MA 01775 (US) YU, Xiang, Y. Acton, MA 01720 (US) LOBERA, Mercedes Concord, MA 01742 (US) LIN, Jian Walpole, MA 01730 (US) CHERUKU, Srinivasa, R. Lexington, MA 02420 (US) BECKER, Oren Mevaseret Zion (IL) MARANTZ, Yael Kadima (IL) SCHUTZ, Nili Tel-aviv (IL) BURLI, Roland Pasadena, CA 91101 (US) CEE, Victor, J. Thousand Oaks, CA 91362 (US) GOLDEN, Jennifer Simi Valley, CA 93063 (US) LANMAN, Brian, Alan Oak Park, CA 91377 (US) NEIRA, Susana Thousand Oaks, CA 91362 (US) ORBACH, Pini Needham, MA 02492 (US) McCAULEY, Dilara. Cambridge, MA 02141 (US) SHARADENDU, Anurag. Washington DC 20016 (US) SHACHAM, Sharon. Chestnut Hill, MA 02467 (US) PENLAND, Robert.C. Watertown MA 02472 (US) NOIMAN, Silvia. Herzliyya (IL) GANNON, Kimberley. Watertown MA 02472 (US) ZHANG, Zhaoda. Andover MA 01810 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Leopoldstrasse 4 80802 München 80802 München (DE)