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EP 2 121 985 A2

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(88) Date of publication A3: 24.12.2008 (43) Date of publication: 25.11.2009 Bulletin 2009/48 (21) Application number: 08727164.9 (22) Date of filing: 27.03.2008

(51) International Patent Classification (IPC):  C12Q 1/68(2006.01) C07H 21/02(2006.01) (86) International application number: PCT/US2008/003964 (87) International publication number: WO 2008/118469 (02.10.2008 Gazette 2008/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 27.03.2007 US 907271 P 27.06.2007 US 929432 P (71) Applicants: Duke University Durham, NC 27708-0083 (US) Université de Lausanne 1015 Lausanne (CH)

(72) Inventors: GOLDSTEIN, David, B. Durham, NC 27708-0083 (US) TELENTI, Amalio CH-1015 Lausanne (CH) FELLAY, Jacques Durham, NC 27708-0083 (US) SHIANNA, Kevin, V. Durham, NC 27708-0083 (US) GE, Dongliang Durham, NC 27708-0083 (US) HAYNES, Barton, F. Durham, NC 27708-0083 (US) (74) Representative: Atkinson, Peter Birch et al Marks & Clerk LLP Sussex House 83-85 Mosley Street Manchester M2 3LG Manchester M2 3LG (GB)