(19)
(11) EP 2 122 344 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
21.08.2019 Bulletin 2019/34

(45) Mention of the grant of the patent:
08.05.2019 Bulletin 2019/19

(21) Application number: 08709448.8

(22) Date of filing: 18.02.2008
(51) International Patent Classification (IPC): 
G01N 33/487(2006.01)
G01N 33/92(2006.01)
(86) International application number:
PCT/GB2008/000562
(87) International publication number:
WO 2008/102120 (28.08.2008 Gazette 2008/35)

(54)

LIPID BILAYER SENSOR SYSTEM

LIPIDDOPPELSCHICHT-SENSORSYSTEM

SYSTÈME DE CAPTEUR BICOUCHE LIPIDIQUE


(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

(30) Priority: 20.02.2007 GB 0703257
20.02.2007 GB 0703256

(43) Date of publication of application:
25.11.2009 Bulletin 2009/48

(73) Proprietor: Oxford Nanopore Technologies Limited
Oxford, Oxfordshire OX4 4DQ (GB)

(72) Inventors:
  • SANGHERA, Gurdial, Singh
    Oxford OX2 8HT (GB)
  • WHITE, Steven, Paul
    Oxford OX2 7PZ (GB)
  • REID, Terrence, Alan
    Oxon OX26 6BG (GB)

(74) Representative: Stanners, David Ralph 
Oxford Nanopore Technologies Ltd. Gosling Building Edmund Halley Road Oxford Science Park
Oxford OX4 4DQ
Oxford OX4 4DQ (GB)


(56) References cited: : 
EP-A2- 0 306 158
US-A- 3 799 743
US-B1- 6 863 833
WO-A-98/58248
US-A1- 2003 098 248
US-B1- 7 077 939
   
  • SHIM JI WOOK ET AL: "Stochastic sensing on a modular chip containing a single-ion channel." ANALYTICAL CHEMISTRY, vol. 79, no. 6, 9 February 2007 (2007-02-09), pages 2207-2213, XP002482461 Web Release ISSN: 0003-2700
  • BEZRUKOV S M ET AL: "COUNTING POLYMERS MOVING THROUGH A SINGLE ION CHANNEL" NATURE, NATURE PUBLISHING GROUP, LONDON, vol. 370, 28 July 1994 (1994-07-28), pages 279-281, XP002944393 ISSN: 0028-0836
  • SCHMIDT C ET AL: "A CHIP-BASED BIOSENSOR FOR THE FUNCTIONAL ANALYSIS OF SINGLE ION CHANNELS" ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, WILEY VCH VERLAG, WEINHEIM, vol. 39, no. 3137, 1 January 2000 (2000-01-01), pages 3137-3140, XP001002622 ISSN: 1433-7851
  • KASIANOWICZ JOHN J ET AL: "Protonation dynamics of the alpha-toxin ion channel from spectral analysis of pH-dependent current fluctuations" BIOPHYSICAL JOURNAL, vol. 69, no. 1, 1995, pages 94-105, XP002482462 ISSN: 0006-3495
  • ROEMER WINFRIED ET AL: "Impedance analysis and single-channel recordings on nano-black lipid membranes based on porous alumina." BIOPHYSICAL JOURNAL, vol. 86, no. 2, February 2004 (2004-02), pages 955-965, XP002482463 ISSN: 0006-3495
  • MONTAL M ET AL: "FORMATION OF BIMOLECULAR MEMBRANES FROM LIPID MONOLAYERS AND A STUDY OF THEIR ELECTRICAL PROPERTIES" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 69, no. 12, 1 December 1972 (1972-12-01), pages 3561-3566, XP009006007 ISSN: 0027-8424
  • SANG-KYU LEE ET AL: "Ion channel switch array: A biosensor for detecting multiple pathogens", INDUSTRIAL BIOTECHNOLOGY, MARY ANN LIEBERT, US, vol. 1, no. 1, 1 March 2005 (2005-03-01), pages 26-31, XP008096693, ISSN: 1550-9087, DOI: 10.1089/IND.2005.1.26
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).