(19)

(11)

EP 2 124 949 A1

(12)

(43) Date of publication: 02.12.2009 Bulletin 2009/49 (21) Application number: 08730525.6 (22) Date of filing: 22.02.2008

(51) International Patent Classification (IPC):  A61K 31/47(2006.01) A01N 43/54(2006.01) A01N 43/42(2006.01) (86) International application number: PCT/US2008/054735 (87) International publication number: WO 2008/103914 (28.08.2008 Gazette 2008/35)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 23.02.2007 US 891272 P (71) Applicant: Avera Pharmaceuticals, Inc. San Diego CA 92122 (US)

(72) Inventors: KEMMERER, Christopher, J. San Diego, CA 92130 (US) CHAPMAN, Dennis Hercules, CA 94547 (US) MCKELVEY, Jeff, F. San Diego, CA 92121 (US) SIFFERT, Jao, O. San Diego, CA 92121 (US) JOHNSON, Richard Del Mar, CA 92014 (US) (74) Representative: Williams, Gareth Owen et al Marks & Clerk LLP 62-68 Hills Road Cambridge, Cambridgeshire CB2 1LA 62-68 Hills Road Cambridge, Cambridgeshire CB2 1LA (GB)