ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIRO..CY..TRBGCZEEHUPLSK....IS..MT..........................*JJDIM360 Ver 1.28 (29 Oct 2014) - 2999001/0The file contains technical information submitted after the application was filed and not included in this specification2125029CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120161214W173deBibliographieenBibliographyfrBibliographieEP07856911.8200712192009071020120119enenen0607723420061219EP2016121420165020091202200949201610122016412016050220161214201650A61K 47/48 20060101AFI20090728BHEP C07H 21/00 20060101ALI20090728BHEP A61P 35/00 20060101ALI20090728BHEP A61P 43/00 20060101ALI20090728BHEP A61K 9/127 20060101ALI20090728BHEP deKONSTRUKTION UND VERWENDUNG VON TRANSFEKTIONS-VERSTÄRKUNGSELEMENTENenCONSTRUCTION AND USE OF TRANSFECTION ENHANCER ELEMENTSfrCONSTRUCTION ET UTILISATION D'ÉLÉMENTS AMÉLIORANT LA TRANSFECTIONEP-A- 1 935 434WO-A-00/59474WO-A-01/51689WO-A-93/15742WO-A-96/05218WO-A-96/07392WO-A-97/40854WO-A-98/32467WO-A-2006/053646WO-A-2008/074487US-A1- 2004 116 687US-A1- 2005 164 963US-B1- 6 989 434HENRY SCOTT M ET AL: "pH-responsive poly(styrene-alt-maleic anhydride) alkylamide copolymers for intracellular drug delivery" BIOMACROMOLECULES, vol. 7, no. 8, August 2006 (2006-08), pages 2407-2414, XP002454257 ISSN: 1525-7797CHEUNG CHARLES Y ET AL: "A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer" BIOCONJUGATE CHEMISTRY, vol. 12, no. 6, November 2001 (2001-11), pages 906-910, XP002454175 ISSN: 1043-1802FATTAL E ET AL: ""Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes" ADVANCED DRUG DELIVERY REVIEWS 23 APR 2004 NETHERLANDS, vol. 56, no. 7, 23 April 2004 (2004-04-23), pages 931-946, XP002454176 ISSN: 0169-409XMATRAY TRACY J ET AL: "Synthesis of oligonucleotides containing 3'-alkylcarboxylic acids using a palladium labile oligonucleotide solid phase synthesis support" BIOCONJUGATE CHEMISTRY, vol. 8, no. 2, 1997, pages 99-102, XP002504282 ISSN: 1043-1802REMY J-S ET AL: "GENE TRANSFER WITH A SERIES OF LIPOPHILIC DNA-BINDING MOLECULES" BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 5, no. 6, 1 November 1994 (1994-11-01), pages 647-654, XP000484178 ISSN: 1043-1802ZHOU X ET AL: "LIPOPHILIC POLYLYSINES MEDIATE EFFICIENT DNA TRANSFECTION IN MAMMALIAN CELLS" BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 1065, no. 1, 31 May 1991 (1991-05-31), pages 8-14, XP000197616 ISSN: 0005-2736SOCHANIK ALEKSANDER ET AL: "In vivo gene transfer using cetylated polyethylenimine" ACTA BIOCHIMICA POLONICA, vol. 51, no. 3, 2004, pages 693-702, XP002511892 ISSN: 0001-527XPOTIER P ET AL: "Synthesis and hybridization properties of oligonucleotides containing polyamines at the C-2 position of purines: a pre-synthetic approach for the incorporation of spermine into oligodeoxynucleotides containing 2-(4,9,13-triazatridecyl)-2'-deoxyguanosin e" CHEMISTRY - A EUROPEAN JOURNAL, WILEY - V C H VERLAG GMBH & CO. KGAA, WEINHEIM, DE, vol. 6, no. 22, 17 November 2000 (2000-11-17), pages 4188-4194, XP002454258 ISSN: 0947-6539TAKEDA TADAYUKI ET AL: "NUCLEOSIDES AND NUCLEOTIDES. LXXVI. SYNTHESIS AND PROPERTIES OF DEOXYOLIGONUCLEOTIDES CONTAINING PUTRESCINYLTHYMINE" CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, vol. 35, no. 9, 1 January 1987 (1987-01-01), pages 3558-3567, XP001248435 ISSN: 0009-2363RAMASAMY K S ET AL: "REMARKABLE ENHANCEMENT OF BINDING AFFINITY OF HETEROCYCLE-MODIFIED DNA TO DNA AND RNA. SYNTHESIS, CHARACTERIZATION AND BIOPHYSICAL EVALUATION ON N2- IMIDAZOLYLPROPYLGUANINE AND N2-IMIDAZOLYLPROPYL-2AMINOADENINE MODIFIED OLIGONUCLEOTIDES" TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 35, no. 2, 10 January 1994 (1994-01-10), pages 215-218, XP002052846 ISSN: 0040-4039HASHIMOTO HIROMASA ET AL: "Zwitterionic DNA" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, no. 16, 1993, pages 7128-7134, XP002512015 ISSN: 0002-7863FRALEY A W ET AL: "Cationic oligonucleotide-peptide conjugates with aggregating properties enter efficiently into cells while maintaining hybridization properties and enzymatic recognition" JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 20060823 US, vol. 128, no. 33, 23 August 2006 (2006-08-23), pages 10763-10771, XP002512016 ISSN: 0002-7863SANEYOSHI H ET AL: "A General Method for the Synthesis of 2'-O-Cyanoethylated Oligoribonucleotides Having Promising Hybridization Affinity for DNA and RNA and Enhanced Nuclease Resistance" JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US, vol. 70, no. 25, 1 January 2005 (2005-01-01), pages 10453-10460, XP003017305 ISSN: 0022-326316192700.920161006PANZNER, SteffenHerweghstr. 706114 HalleDELipocalyx GmbH101359446EA-PCT--15624Weinbergweg 2306120 HalleDEBlodig, Wolfgang101167774Wächtershäuser & Hartz Patentanwaltspartnerschaft mbB Weinstrasse 880333 MünchenDEATBEBGCHCYCZDEDKEEESFIFRGBGRHUIEISITLILTLULVMCMTNLPLPTROSESISKTREP200701118820071219enWO200807448820080626200826