(19)

(11)

EP 2 125 719 A1

(12)

(43) Date of publication: 02.12.2009 Bulletin 2009/49 (21) Application number: 08730988.6 (22) Date of filing: 28.02.2008

(51) International Patent Classification (IPC):  C07D 209/12(2006.01) A61K 31/404(2006.01) A61P 35/00(2006.01) A61P 19/10(2006.01) C07F 9/572(2006.01) A61K 31/6615(2006.01) A61P 5/30(2006.01) (86) International application number: PCT/US2008/055326 (87) International publication number: WO 2008/106600 (04.09.2008 Gazette 2008/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 28.02.2007 US 892044 P (71) Applicant: Wyeth Madison, NJ 07940 (US)	(72) Inventors: FAWZI, Mahdi, B. Morristown, NJ 07960 (US) ZHU, Tianmin Monroe, NY 10950 (US) PAN, Weitao Belle Mead, NJ 08502 (US) (74) Representative: Talbott, Dawn Jacqueline  Wyeth Pharmaceuticals, Huntercombe Lane South, Taplow Maidenhead, Berkshire SL6 0PH Maidenhead, Berkshire SL6 0PH (GB)