(19)

(11)

EP 2 125 890 A2

(12)

(88) Date of publication A3: 18.12.2008 (43) Date of publication: 02.12.2009 Bulletin 2009/49 (21) Application number: 08713167.8 (22) Date of filing: 18.01.2008

(51) International Patent Classification (IPC):  C07K 16/18(2006.01) G01N 33/53(2006.01) G01N 33/573(2006.01) C12N 5/12(2006.01) C07K 16/40(2006.01) G01N 33/566(2006.01) G01N 33/68(2006.01) (86) International application number: PCT/US2008/000639 (87) International publication number: WO 2008/091535 (31.07.2008 Gazette 2008/31)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 19.01.2007 US 881190 P (71) Applicant: Biogen Idec MA Inc. Cambridge, Massachusetts 02142 (US)	(72) Inventors: GORELIK, Leonid Quincy, MA 02171 (US) BAKER, Darren, P. Hingham, MA 02043 (US) HESSION, Catherine, A. Hingham, MA 02043 (US) VAN DE MARK, Karyn Woburn, MI 01801 (US) ARDUNINI, Robert, M. Charlestown, MA 02129 (US) WILDES, Craig Cambridge, MA 02142 (US) (74) Representative: Adams, Harvey Vaughan John et al Mathys & Squire LLP 120 Holborn London EC1N 2SQ London EC1N 2SQ (GB)