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(11)

EP 2 131 839 A2

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(43) Date of publication: 16.12.2009 Bulletin 2009/51 (21) Application number: 08731122.1 (22) Date of filing: 29.02.2008

(51) International Patent Classification (IPC):  A61K 31/4164(2006.01) A61K 31/50(2006.01) A61K 31/502(2006.01) A61K 31/551(2006.01) A61P 25/00(2006.01) A61K 31/426(2006.01) A61K 31/501(2006.01) A61K 31/506(2006.01) A61P 25/08(2006.01) (86) International application number: PCT/US2008/055495 (87) International publication number: WO 2008/109437 (12.09.2008 Gazette 2008/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 02.03.2007 US 904606 P 27.11.2007 US 4385 P (71) Applicant: Northwestern University Evanston, IL 60608 (US)	(72) Inventors: WATTERSON, D. Martin Chicago, IL 60611 (US) VAN ELDIK, Linda, J. Chicago, IL 60611 (US) WAINWRIGHT, Mark, S. Evanston, IL 60201 (US) (74) Representative: Holliday, Louise Caroline et al D Young & Co 120 Holborn London EC1N 2DY London EC1N 2DY (GB)