(19)

(11)

EP 2 134 843 A1

(12)

(43) Date of publication: 23.12.2009 Bulletin 2009/52 (21) Application number: 08733487.6 (22) Date of filing: 14.03.2008

(51) International Patent Classification (IPC):  C12N 15/12(2006.01) C07K 14/435(2006.01) A61K 38/57(2006.01) A61P 35/00(2006.01) C12N 15/15(2006.01) C07K 14/745(2006.01) A61P 7/02(2006.01) (86) International application number: PCT/BR2008/000078 (87) International publication number: WO 2008/109976 (18.09.2008 Gazette 2008/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 14.03.2007 US 724557 (71) Applicants: União Química Farmacêutica Nacional S/A 04071-900 São Paulo (BR) Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP 05468-901 São Paulo (BR) Chudzinski-Tavassi, Ana Marisa Rua Antonio Gonçalves da Cruz 60 Apto 111A 05503-900 São Paulo - Sp (BR)

(72) Inventors: CHUDZINSKI-TAVASSI, Ana Marisa 05503-900 São Paulo - Sp (BR) MARIA, Durvanei Augusto 05503-900 São Paulo - Sp (BR) HO, Paulo Lee 05503-900 São Paulo - Sp (BR) BATISTA, Isabel de Fátima Correia 05503-900 São Paulo (BR) (74) Representative: Blot, Philippe Robert Emile et al Cabinet Lavoix 2, place d'Estienne d'Orves 75441 Paris Cedex 09 75441 Paris Cedex 09 (FR)