PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF

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EP 2 137 191 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	08.06.2016 Bulletin 2016/23

(45)	Mention of the grant of the patent:
	02.03.2016 Bulletin 2016/09

(21)	Application number: 08742363.8

(22)	Date of filing: 28.03.2008

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International Patent Classification (IPC):

C07D 489/04^(2006.01)
A61P 43/00^(2006.01)

A61K 31/439^(2006.01)

(86)	International application number:
	PCT/US2008/004109

(87)	International publication number:
	WO 2008/121348 (09.10.2008 Gazette 2008/41)

(54)	PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF ANTAGONISTEN DER PERIPHEREN OPIOIDREZEPTOREN UND IHRE VERWENDUNG ANTAGONISTES DE RÉCEPTEURS OPIOÏDES PÉRIPHÉRIQUES, ET LEURS UTILISATIONS

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

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Priority:

29.03.2007 US 921123 P

(43)	Date of publication of application:
	30.12.2009 Bulletin 2009/53

(60)	Divisional application:
	16155008.2

(73)	Proprietors:
	Progenics Pharmaceuticals, Inc. Tarrytown, NY 10591 (US) Wyeth LLC (Formerly Known As Wyeth) New York, NY 10017 (US)

(72)	Inventors:
	AVEY, Alfred, A. Eugene, OR 07405 (US) PEREZ, Julio Tarrytown, NY 10591 (US) DOSHAN, Harold, D. Riverside, CT 06878 (US) CHANDRASEKARAN, Appavu Plainsboro, NJ 08536 (US) ROTSHTEYN, Yakov Monroe, NY 10950 (US)

(74)	Representative: Russell, Tim
	Venner Shipley LLP 200 Aldersgate London EC1A 4HD London EC1A 4HD (GB)

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References cited: :

WO-A-2006/127899

UWAI, KOJI ET AL.: BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, 2004, pages 417-421, XP002499242
LAZAR S ET AL: "SYNTHESIS AND BIOLOGICAL ACTIVITY OF THE PHOSPHATE AND SULFATE ESTERS OF NALOXONE AND NALTREXONE" EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 29, no. 1, 1 January 1994 (1994-01-01), pages 45-54, XP009084006 ISSN: 0223-5234
MALSPEIS L ET AL: "METABOLIC REDUCTION OF NALTEXONE I. SYNTHESIS, SEPARATION AND CHARACTERIZATION OF NALOXONE AND NALTREXONE REDUCTION PRODUCTS AND QUALITATIVE ASSAY OF URINE AND BILE FOLLOWING ADMINISTRATION OF NALTREXONE, ALPHA-NALTREXOL, OR BETA-NALTREXOL" RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, PJD PUBLICATIONS LTD., WESTBURY, NY, US, vol. 12, no. 1, 1 September 1975 (1975-09-01), pages 43-65, XP008097305 ISSN: 0034-5164

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).