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(11)

EP 2 139 522 A2

(12)

(88) Date of publication A3: 06.11.2008 (43) Date of publication: 06.01.2010 Bulletin 2010/01 (21) Application number: 08731532.1 (22) Date of filing: 06.03.2008

(51) International Patent Classification (IPC):  A61K 47/48(2006.01) C07D 211/94(2006.01) A61K 31/66(2006.01) A61P 35/00(2006.01) C07D 207/46(2006.01) C07F 9/54(2006.01) A61K 31/4468(2006.01) A61P 35/02(2006.01) (86) International application number: PCT/US2008/056035 (87) International publication number: WO 2008/109740 (12.09.2008 Gazette 2008/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 06.03.2007 US 905237 P (71) Applicants: Colby Pharmaceutical Company Menlo Park, CA 94025 (US) Medical College Of Wisconsin, Inc. Milwaukee, WI 53226 (US)	(72) Inventors: ZARLING, David, A. Menlo Park, CA 94025 (US) BASU, Hirak, S. Madison, WI 53717 (US) KALYANARAMAN, Balaraman Wauwatosa, WI 53226 (US) JOSEPH, Joy New Berlin, WI 53151 (US) (74) Representative: Purdy, Hugh Barry et al PurdyLucy Intellectual Property Suite 138/139 The Capel Building Mary's Abbey Dublin 7 Dublin 7 (IE)