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EP 2 139 883 A2

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(88) Date of publication A3: 18.12.2008 (43) Date of publication: 06.01.2010 Bulletin 2010/01 (21) Application number: 08744245.5 (22) Date of filing: 24.03.2008

(51) International Patent Classification (IPC):  C07D 401/12(2006.01) A61K 31/195(2006.01) A61K 31/425(2006.01) C07K 19/00(2006.01) (86) International application number: PCT/US2008/058004 (87) International publication number: WO 2008/118849 (02.10.2008 Gazette 2008/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 23.03.2007 US 919819 P 23.03.2007 US 919896 P 04.06.2007 US 941829 P 04.06.2007 US 941786 P (71) Applicants: University of Massachusetts Boston, MA 02108 (US) UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE Baltimore, MD 21202 (US) MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 02142-1324 (US)

(72) Inventors: ALI, Akbar Worcester, MA 01604 (US) ALTMAN, Michael, D. Cambridge, MA 02140 (US) ANJUM, Saima, Ghafoor Shrewsbury, MA 01545 (US) CAO, Hong Westborough, MA 01581 (US) CHELLAPPAN, Sripriya Gaithersburg, MD 20886 (US) FERNANDES, Miguel, X. P-9000-390 Funchal (PT) GILSON, Michael North Potomac, MD 20887 (US) KAIRYS, Visvaldas LT003134 Vilnius (LT) KING, Nancy Oxford, MA 01540 (US) NALIVAIKA, Ellen Worcester, MA 01604 (US) PRABU, Moses Worcester, MA 01605 (US) RANA, Tariq, M. Shrewsbury, MA 01545 (US) GARUDAMMAGARI SAI, Kiran Kumar, Reddy Wilmington, MA 01887 (US) SCHIFFER, Celia, A. Shrewsbury, MA 01545 (US) TIDOR, Bruce Lexington, MA 02421 (US) NALAM, Madhavi, Naga, Laxmi Worcester, MA 01606 (US) (74) Representative: Crooks, Elizabeth Caroline et al Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)