(19)

(11)

EP 2 142 645 A2

(12)

(88) Date of publication A3: 19.03.2009 (43) Date of publication: 13.01.2010 Bulletin 2010/02 (21) Application number: 08745063.1 (22) Date of filing: 04.04.2008

(51) International Patent Classification (IPC):  C12N 9/64(2006.01) A61K 39/395(2006.01) C07K 16/40(2006.01) (86) International application number: PCT/US2008/059335 (87) International publication number: WO 2008/130814 (30.10.2008 Gazette 2008/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR (30) Priority: 18.04.2007 US 912433 P 01.10.2007 US 976570 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, IN 46285 (US)	(72) Inventor: WERNER, Sean, Richard Indianapolis, Indiana 46228 (US) (74) Representative: Ingham, Stephen H.  Eli Lilly and Company Ltd European Patent Operations Lilly Research Centre Erl Wood Manor Sunninghill Road Windlesham, Surrey, GU20 6PH Windlesham, Surrey, GU20 6PH (GB)