(19)

(11)

EP 2 144 622 A1

(12)

(43) Date of publication: 20.01.2010 Bulletin 2010/03 (21) Application number: 08745659.6 (22) Date of filing: 11.04.2008

(51) International Patent Classification (IPC):  A61K 38/18(2006.01) (86) International application number: PCT/US2008/060098 (87) International publication number: WO 2008/128093 (23.10.2008 Gazette 2008/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 13.04.2007 US 911857 P 15.06.2007 US 944409 P 18.07.2007 US 779743 08.08.2007 US 954777 P 04.02.2008 US 26023 (71) Applicant: PHARMACYCLICS, INC. Sunnyvale, CA 94085 (US)	(72) Inventors: BALASUBRAMANIAN, Sriram San Carlos, CA 94070 (US) BUGGY, Joseph, J. Mountain View, CA 94040 (US) RAMOS, Jason San Leandro, CA 94579 (US) SIRISAWAD, Mint Mountain View, CA 94043 (US) (74) Representative: Cole, William Gwyn et al HLBBshaw Merlin House Falconry Court Baker's Lane GB-Epping, Essex CM16 5DQ GB-Epping, Essex CM16 5DQ (GB)