| (84) |
Designated Contracting States: |
|
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL
PT RO SE SI SK TR |
| (30) |
Priority: |
10.04.2007 US 922742 P
|
| (43) |
Date of publication of application: |
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27.01.2010 Bulletin 2010/04 |
| (73) |
Proprietor: Helsinn Healthcare SA |
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6912 Lugano-Pazzallo (CH) |
|
| (72) |
Inventors: |
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- MANN, William, R.
Sparta, NJ 07871 (US)
- POLVINO, William, J.
Tinton Falls, NJ 07724 (US)
|
| (74) |
Representative: Zardi, Marco et al |
|
M. Zardi & Co. S.A.
Via Pioda 6
6900 Lugano
6900 Lugano (CH) |
| (56) |
References cited: :
WO-A1-01/34593
US-A1- 2007 021 331
US-B1- 6 303 620
US-B2- 6 576 648
|
US-A1- 2005 277 677
US-A1- 2007 037 751
US-B1- 6 919 315
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- LIU Y-L ET AL: "Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents."
September 2006 (2006-09), CANCER CHEMOTHERAPY AND PHARMACOLOGY SEP 2006 LNKD- PUBMED:16435157,
VOL. 58, NR. 3, PAGE(S) 326 - 333 , XP19423295 ISSN: 0344-5704 * See abstract: ghrelin
(a growth hormone secretagogue) alleviates dyspepsia (which includes vomiting) associated
with chemotherapy *
- RUDD JOHN A ET AL: "Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic
anti-cancer agent cisplatin." 9 January 2006 (2006-01-09), NEUROSCIENCE LETTERS 9
JAN 2006 LNKD- PUBMED:16182445, VOL. 392, NR. 1-2, PAGE(S) 79 - 83 , XP25024067 ISSN:
0304-3940 * See abstract: ghrelin, which is a growth hormone secretagogue provides
a novel approach in the treatment of emesis *
- PAUL, BERNHARD J. ET AL: "A Practical Synthesis of the Pseudotripeptide RC - 1291"
ORGANIC PROCESS RESEARCH & DEVELOPMENT , 10(2), 339-345 CODEN: OPRDFK; ISSN: 1083-6160,
2006, XP002590175
- YANG L ET AL: "1-[2(R)-(2-amino-2-methylpropionylamino)- 3-(1H-indol-3-yl)propionyl]-
3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally
bioavailable, and short-duration growth hormone secretagogue." 2 July 1998 (1998-07-02),
JOURNAL OF MEDICINAL CHEMISTRY 2 JUL 1998 LNKD- PUBMED:9651148, VOL. 41, NR. 14, PAGE(S)
2439 - 2441 , XP002590176 ISSN: 0022-2623 * See preparation of L 163,540 a compound
structurally related to RC-1291, and its activity as growth hormone secretagogue *
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