(19)

(11)

EP 2 150 564 A2

(12)

(88) Date of publication A3: 24.12.2008 (43) Date of publication: 10.02.2010 Bulletin 2010/06 (21) Application number: 08754949.9 (22) Date of filing: 28.04.2008

(51) International Patent Classification (IPC):  C07K 16/24(2006.01) A61K 39/395(2006.01) C07K 16/46(2006.01) A61P 37/06(2006.01) (86) International application number: PCT/US2008/061815 (87) International publication number: WO 2008/134659 (06.11.2008 Gazette 2008/45)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 27.04.2007 US 914681 P 27.04.2007 US 914663 P 27.04.2007 US 741189 13.06.2007 US 762738 (71) Applicant: ZymoGenetics, Inc. Seattle, Washington 98102 (US)	(72) Inventors: LEWIS, Katherine, E. Lake Forest Park, Washington 98155 (US) PRESNELL, Scott, R. Tacoma, Washington 98407 (US) LEVIN, Steven, D. Seattle, Washington 98177 (US) (74) Representative: MacLean, Martin Robert  Mathys & Squire LLP 120 Holborn London EC1N 2SQ London EC1N 2SQ (GB)