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EP 2 155 678 A1

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(43) Date of publication: 24.02.2010 Bulletin 2010/08 (21) Application number: 08736022.8 (22) Date of filing: 09.04.2008

(51) International Patent Classification (IPC):  C07D 211/58(2006.01) C07D 401/12(2006.01) C07D 409/14(2006.01) A61K 31/4523(2006.01) C07D 211/96(2006.01) C07D 409/12(2006.01) C07D 413/12(2006.01) A61P 29/00(2006.01) (86) International application number: PCT/EP2008/054298 (87) International publication number: WO 2008/125570 (23.10.2008 Gazette 2008/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 12.04.2007 EP 07106014 (71) Applicant: EVOTEC Neurosciences GmbH 22525 Hamburg (DE)	(72) Inventors: MADDEN, James Wokingham RG41 5HX (GB) HALLETT, David Marlow SL7 3QY (GB) TAYLOR, Steven Didcot OX11 7AU (GB) RAJU, Gurubaran Shirley B90 3LZ (GB) WANG, Xiaolu 22457 Hamburg (DE) GEMKOW, Mark 22457 Hamburg (DE) (74) Representative: Büchel, Edwin  Isenbruck Bösl Hörschler Wichmann LLP Eastsite One Seckenheimer Landstrasse 4 68163 Mannheim 68163 Mannheim (DE)