(19)

(11)

EP 2 160 377 A1

(12)

(43) Date of publication: 10.03.2010 Bulletin 2010/10 (21) Application number: 08774496.7 (22) Date of filing: 27.06.2008

(51) International Patent Classification (IPC):  C07C 245/08(2006.01) A61K 31/575(2006.01) C07J 9/00(2006.01) A61P 1/12(2006.01) (86) International application number: PCT/EP2008/058338 (87) International publication number: WO 2009/003970 (08.01.2009 Gazette 2009/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 29.06.2007 IE 20070475 29.06.2007 US 947104 P (71) Applicant: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin Dublin 2 (IE)	(72) Inventors: GILMER, John Francis Dublin 24 (IE) MARQUEZ, Juan Francisco Dublin 8 (IE) KELLEHER, Dermot Dun Laoghaire Co. Dublin (IE) (74) Representative: Earnshaw, Geoffrey Mark  Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)