| (19) |
 |
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(11) |
EP 2 161 347 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
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16.06.2010 Bulletin 2010/24 |
| (43) |
Date of publication A2: |
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10.03.2010 Bulletin 2010/10 |
| (22) |
Date of filing: 17.03.2006 |
| (27) |
Previously filed application:
17.03.2006 PCT/CN2006/000414 |
|
| (51) |
International Patent Classification (IPC):
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| (84) |
Designated Contracting States: |
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AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE
SI SK TR |
| (30) |
Priority: |
18.03.2005 US 663293 P
|
| (62) |
Application number of the earlier application in accordance with Art. 76 EPC: |
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06722066.5 / 1859051 |
| (71) |
Applicant: The Chinese University Of Hong Kong |
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Shatin, New Territories
Hong Kong (CN) |
|
| (72) |
Inventors: |
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- Lo, Yuk-Ming, Dennis
Hong Kong (CN)
- Chiu, Rossa Wai Kwun
Hong Kong (CN)
- Chim, Stephen, Siu Chung
Hong Kong (CN)
- Tsui, Nancy Bo Yin
Hong Kong (CN)
|
| (74) |
Representative: Krauss, Jan |
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Forrester & Boehmert
Pettenkoferstrasse 20-22
80336 München
80336 München (DE) |
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| |
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| (54) |
Markers for prenatal diagnosis and monitoring |
(57) Methods and kits are provided for diagnosing, monitoring, or predicting preeclaimpsia
in a pregnant woman, trisomy 18 and trisomy 21 in a fetus, as well as for detecting
pregnancy in a woman, by quantitatively measuring in the maternal blood the amount
of one or more RNA species derived from a set of genetic loci and comparing the amount
of the RNA species with a standard control.