(19)

(11)

EP 2 162 743 A2

(12)

(88) Date of publication A3: 05.03.2009 (43) Date of publication: 17.03.2010 Bulletin 2010/11 (21) Application number: 08767898.3 (22) Date of filing: 28.05.2008

(51) International Patent Classification (IPC):  G01N 33/53(2006.01) C07K 16/00(2006.01) (86) International application number: PCT/US2008/006728 (87) International publication number: WO 2008/153790 (18.12.2008 Gazette 2008/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 29.05.2007 US 932095 P (71) Applicant: University Of Cincinnati Cincinnati, OH 45267-0829 (US)	(72) Inventors: FINKELMAN, Fred Cincinnati, OH 45208 (US) KHODOUN, Marat Mason, OH 45040 (US) WILLIS-KARP, Marsha Cincinnati, OH 45267-0829 (US) LEWIS, Christina Cincinnati, OH 45267-0829 (US) (74) Representative: Ouzman, Beverley Nicola Claire  Murgitroyd & Company Scotland House 165-169 Scotland Street Glasgow G5 8PL Glasgow G5 8PL (GB)