(19)

(11)

EP 2 167 059 A2

(12)

(88) Date of publication A3: 12.03.2009 (43) Date of publication: 31.03.2010 Bulletin 2010/13 (21) Application number: 08802942.6 (22) Date of filing: 03.07.2008

(51) International Patent Classification (IPC):  A61K 31/00(2006.01) C07K 14/575(2006.01) (86) International application number: PCT/EP2008/058593 (87) International publication number: WO 2009/004058 (08.01.2009 Gazette 2009/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 05.07.2007 EP 07111799 10.09.2007 WO PCT/EP2007/007863 09.02.2008 EP 08388007 11.02.2008 EP 08101470 13.02.2008 EP 08101589 (71) Applicant: Novo Nordisk A/S 2880 Bagsværd (DK)	(72) Inventors: BREINHOLT, Jens DK-2870 Dyssegard (DK) NIELSEN, Per Franklin DK-2760 Måløv (DK) CHRISTENSEN, Leif DK-4000 Roskilde (DK) NØRSKOV-LAURITSEN, Leif DK-4733 Tappernøje (DK) SVENSSON, Anders S-217 46 Malmö (SE)