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(11)

EP 2 167 071 A2

(12)

(88) Date of publication A3: 19.02.2009 (43) Date of publication: 31.03.2010 Bulletin 2010/13 (21) Application number: 08770940.8 (22) Date of filing: 13.06.2008

(51) International Patent Classification (IPC):  A61K 31/195(2006.01) A61L 9/04(2006.01) A61K 47/00(2006.01) (86) International application number: PCT/US2008/066831 (87) International publication number: WO 2008/157288 (24.12.2008 Gazette 2008/52)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 13.06.2007 US 943729 P (71) Applicants: Wayne State University Board Of Governors Detroit, MI 48202 (US) Phase V. Pharmaceuticals, Inc. Silver Spring, MD 20910 (US)	(72) Inventors: MEYTHALER, Jay, M. Grosse Pointe Farms, MI 48326 (US) TUEL, Stephen, M. Silver Spring, MD 20910 (US) (74) Representative: Whitfield, Gillian Janette et al Astrum-IP Limited 35 Stow Park Circle Newport South Wales NP20 4HF Newport South Wales NP20 4HF (GB)