Synthesis of 2-Hydroxy-N,N-Dimethyl-3-[[2-[1(r) - (5-Methyl-2-Furanyl) Propyl] -3, 4-Dioxo-1-Cyclobuten-1-Yl]amino] Benzamide

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EP 2 168 956 B8

(12)	CORRECTED EUROPEAN PATENT SPECIFICATION
	Note: Bibliography reflects the latest situation

(15)	Correction information:
	Corrected version no 1 (W1 B1)

(48)	Corrigendum issued on:
	01.05.2013 Bulletin 2013/18

(45)	Mention of the grant of the patent:
	20.03.2013 Bulletin 2013/12

(21)	Application number: 09014248.0

(22)	Date of filing: 16.04.2004

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International Patent Classification (IPC):

C07D 307/52^(2006.01)

C07C 205/60^(2006.01)

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Synthesis of 2-Hydroxy-N,N-Dimethyl-3-[[2-[1(r) - (5-Methyl-2-Furanyl) Propyl] -3, 4-Dioxo-1-Cyclobuten-1-Yl]amino] Benzamide

Synthese von 2-hydroxy-n,n-dimethyl-3-[[2-[1(r) - (5-methyl-2-furanyl) propyl] -3, 4-dioxo-1-cyclobuten-1-yl]amino] Benzamid

Synthèse de 2-hydroxy-n,n-dimethyl-3-[[2-[1(r) - (5-methyl-2-furanyl) propyl] -3, 4-dioxo-1-cyclobuten-1-yl]amino] benzamide

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR
	Designated Extension States:
	AL HR LT LV MK

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Priority:

18.04.2003 US 463773 P

(43)	Date of publication of application:
	31.03.2010 Bulletin 2010/13

(62)	Application number of the earlier application in accordance with Art. 76 EPC:
	04759956.8 / 1615903

(73)	Proprietor: Merck Sharp & Dohme Corp.
	Rahway, NJ 07065-0907 (US)

(72)	Inventors:
	Yin, Yianguo Plainsboro NJ 08536 (US) Fu, Xiaoyong Edison NJ 08820 (US) Zhang, Shuyi Parsippany NJ 07054 (US) MacAllister, Timothy L. Westfield NJ 07090 (US) Kim-Meade, Agnes S. Fanwood NJ 07023 (US) Winters, Jason L. East Windsor NJ 08520 (US) Sudhakar, Anantha East Brunswick NJ 08816 (US) Schumacher, Doris P. Bedminster NJ 07921 (US)

(74)	Representative: Horgan, James Michael Frederic
	Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon Hertfordshire EN11 9BU Hoddesdon Hertfordshire EN11 9BU (GB)

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References cited: :

WO-A1-02/083624

SELWOOD ET AL: "Structure-Activity Relationships of Antifilarial Antimycin Analogues: A Multivariate Pattern Recognition Study" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 1, no. 33, 1 January 1990 (1990-01-01), pages 136-142, XP002071789 ISSN: 0022-2623

Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).