(19)

(11)

EP 2 170 816 A1

(12)

(43) Date of publication: 07.04.2010 Bulletin 2010/14 (21) Application number: 08774213.6 (22) Date of filing: 23.06.2008

(51) International Patent Classification (IPC):  C07C 291/04(2006.01) A61P 25/24(2006.01) A61K 31/135(2006.01) (86) International application number: PCT/EP2008/057939 (87) International publication number: WO 2009/000797 (31.12.2008 Gazette 2009/01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 26.06.2007 EP 07111028 26.06.2007 US 946200 P (71) Applicant: Solvay Pharmaceuticals B.V. 1381 CP Weesp (NL)	(72) Inventors: TURSKI, Lechoslaw A. NL-1381 CP Weesp (NL) STOIT, Axel NL-1381 CP Weesp (NL) KRUSE, Cornelis G. NL-1381 CP Weesp (NL) VADER, Sander NL-1381 CP Weesp (NL) TULP, Martinus Th.M. NL-1381 CP Weesp (NL) (74) Representative: Tulp, Martinus et al Octrooibureau Zoan B.V. IPSI P.O. Box 140 1380 AC Weesp 1380 AC Weesp (NL)