(19)

(11)

EP 2 170 892 A2

(12)

(88) Date of publication A3: 12.02.2009 (43) Date of publication: 07.04.2010 Bulletin 2010/14 (21) Application number: 08768351.2 (22) Date of filing: 11.06.2008

(51) International Patent Classification (IPC):  C07D 487/04(2006.01) A61K 31/519(2006.01) C07D 519/00(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/US2008/007295 (87) International publication number: WO 2008/156614 (24.12.2008 Gazette 2008/52)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 14.06.2007 US 943999 P 14.11.2007 US 987932 P (71) Applicant: Schering Corporation Kenilworth, NJ 07033-0530 (US)

(72) Inventors: YU, Tao Edison, NJ 08820 (US) BELANGER, David, B. Cambridge, MA 02139 (US) KEREKES, Angela, D. Scotch Plains, NJ 07076 (US) MENG, Zhaoyang Burlington, MA 10803 (US) TAGAT, Jayaram, R. Westfield, NJ 07090 (US) ESPOSITE, Sara, J. Plainsboro, NJ 08536 (US) MANDAL, Amit, K. Cambridge, MA 02139 (US) XIAO, Yushi Edison, NJ 08837 (US) KULKARNI, Bheemashankar, A. Newton, MA 02460 (US) ZHANG, Yonglian Edison, NJ 08837 (US) CURRAN, Patrick, J. Winthrop, MA 02152 (US) DOLL, Ronald Convent Station, NJ 07960 (US) SIDDIQUI, M. Arshad Newton, MA 02464 (US) (74) Representative: Broekkamp, Chris L. E. et al P.O. Box 20 5340 BH Oss 5340 BH Oss (NL)