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(11)

EP 2 182 949 A1

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(43) Date of publication: 12.05.2010 Bulletin 2010/19 (21) Application number: 08782584.0 (22) Date of filing: 01.08.2008

(51) International Patent Classification (IPC):  A61K 31/4545(2006.01) A61P 25/02(2006.01) A61P 25/16(2006.01) A61P 25/22(2006.01) A61P 25/28(2006.01) A61P 35/00(2006.01) A61P 25/00(2006.01) A61P 25/14(2006.01) A61P 25/18(2006.01) A61P 25/24(2006.01) A61P 29/00(2006.01) A61P 43/00(2006.01) (86) International application number: PCT/US2008/071872 (87) International publication number: WO 2009/018505 (05.02.2009 Gazette 2009/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 02.08.2007 US 953610 P 02.08.2007 US 953613 P 02.08.2007 US 953614 P 12.09.2007 US 971654 P (71) Applicant: Targacept Inc. Winston-Salem, NC 27101 (US)

(72) Inventors: BENCHERIF, Merouane Winston-Salem, North Carolina 27106 (US) BENSON, Lisa Kernersville, North Carolina 27284 (US) DULL, Gary Maurice Lewisville, North Carolina 27023 (US) FEDOROV, Nikolai Winston-salem, North Carolina 27106 (US) GATTO, Gregory J. Winston-salem, North Carolina 27103 (US) GENUS, John Winston-salem, North Carolina 27127 (US) JORDAN, Kristen G. Clemmons, North Carolina 27012 (US) MATHEW, Jacob Winston-salem, North Carolina 27101 (US) MAZUROV, Anatoly A. Greensboro, North Carolina 27410 (US) MIAO, Lan Advance, North Carolina 27006 (US) MUNOZ, Julio A. Walnut Cove, North Carolina 27052 (US) PFEIFFER, Inigo Kernersville, North Carolina 27284 (US) PFEIFFER, Sondra Kernersville, North Carolina 27284 (US) PHILLIPS, Teresa Y. Greensboro, North Carolina 27406 (US) (74) Representative: Crowhurst, Charlotte Waveney  Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)