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EP 2 185 154 A2

(12)

(88) Date of publication A3: 23.12.2009 (43) Date of publication: 19.05.2010 Bulletin 2010/20 (21) Application number: 08794839.4 (22) Date of filing: 29.07.2008

(51) International Patent Classification (IPC):  A61K 31/497(2006.01) A61P 11/06(2006.01) A61P 17/14(2006.01) A61P 29/00(2006.01) A61P 37/06(2006.01) A61P 11/00(2006.01) A61P 17/00(2006.01) A61P 19/02(2006.01) A61P 37/00(2006.01) A61K 45/06(2006.01) (86) International application number: PCT/US2008/009149 (87) International publication number: WO 2009/020534 (12.02.2009 Gazette 2009/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 03.08.2007 US 953770 P (71) Applicants: Schering Corporation Kenilworth, New Jersey 07033 (US) Pharmacopeia, LLC La Jolla, CA 92037 (US)

(72) Inventors: FINE, Jay, S. Bloomfield, New Jersey 07003 (US) KIM, Seong, Heon Livingston, New Jersey 07039 (US) ANILKUMAR, Gopinadhan, N. Edison, New Jersey 08820 (US) WONG, Michael, K. C. North Brunswick, New Jersey 08902 (US) ZENG, Qingbei Edison, New Jersey 08820 (US) ROSENBLUM, Stuart, B. West Orange, New Jersey 07052 (US) KOZLOWSKI, Joseph, A. Princeton, New Jersey 08540 (US) SHAO, Yuefei Princeton, New Jersey 08540 (US) MCGUINNESS, Brian, F. Plainsboro, New Jersey 08536 (US) HOBBS,, Douglas, W. Chesterfield, Missouri 63005 (US) (74) Representative: Broekkamp, Chris L. E. et al P.O. Box 20 5340 BH Oss 5340 BH Oss (NL)