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EP 2 185 537 A1

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(43) Date of publication: 19.05.2010 Bulletin 2010/20 (21) Application number: 08789003.4 (22) Date of filing: 29.07.2008

(51) International Patent Classification (IPC):  C07D 401/04(2006.01) C07D 403/04(2006.01) C07D 405/14(2006.01) A61K 31/44(2006.01) A61P 19/00(2006.01) C07D 401/14(2006.01) C07D 405/04(2006.01) C07D 413/14(2006.01) A61K 31/506(2006.01) A61P 35/00(2006.01) (86) International application number: PCT/IB2008/002046 (87) International publication number: WO 2009/016498 (05.02.2009 Gazette 2009/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 02.08.2007 US 953604 P 20.12.2007 US 15533 (71) Applicant: Pfizer Inc. New York, NY 10017 (US)

(72) Inventors: SCHNUTE, Mark, E. Dardenne Prairie, MO 63368 (US) CARROLL, Jeffery, Neal St. Louis, MO 63125 (US) HANAU, Cathleen, Elizabeth Chesterfield, MO 63017 (US) MCREYNOLDS, Matthew, David St. Louis, MO 63119 (US) SCHOLTEN, Jeffrey, Allen Chesterfield, MO 63005 (US) MCDONALD, Joseph, J. Wildwood, MO 63011 (US) GRAPPERHAUS, Margaret, L. Troy, IL62294 (US) MASSA, Mark, Alan Chesterfield, MO 63017 (US) RUMINSKI, Peter, G. Ballwin, MO 63021 (US) SCHMIDT, Michelle, Ann Millstadt, IL 62260 (US) STROHBACH, Joseph, Walter Wentzville, MO 63385 (US) HAMPER, Bruce, Cameron Kirkwood, MO 63122 (US) FLETCHER, Theresa, R. Chesterfield, MO 63017 (US) ROGERS, Michael, David Maryland Heights, MO 63043 (US) O'BRIEN, Patrick, Michael Stockbridge, MI 49285 (US) NAHRA, Joe Ewing, NJ 08628 (US) MORRIS, Mark, Anthony Arlington, MA 02474 (US) ROARK, William, Howard Ann Arbor, MI 48104 (US) (74) Representative: Brunetti, Fabrizio  Pfizer European Patent Department 23-25 avenue du Docteur Lannelongue 75668 Paris Cedex 14 75668 Paris Cedex 14 (FR)