(19)

(11)

EP 2 187 894 A2

(12)

(88) Date of publication A3: 24.09.2009 (43) Date of publication: 26.05.2010 Bulletin 2010/21 (21) Application number: 08835075.6 (22) Date of filing: 18.08.2008

(51) International Patent Classification (IPC):  A61K 31/7076(2006.01) A61P 39/00(2006.01) A61K 33/32(2006.01) (86) International application number: PCT/US2008/073479 (87) International publication number: WO 2009/045655 (09.04.2009 Gazette 2009/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR Designated Extension States: AL BA MK RS (30) Priority: 16.08.2007 US 935494 P (71) Applicants: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Rockville, MD 20852 (US) The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Rockville, MD 20852 (US)

(72) Inventors: DALY, Michael, J. Washington DC 20005 (US) GAIDAMAKOVA, Elena, K. Gaithersburg Maryland 20878 (US) MATROSOVA, Vera K. Rockville Maryland 20850 (US) LEVINE, Rodney L. Rockville Maryland 20850 (US) WEHR, Nancy B. Bethesda Maryland 20816 (US) (74) Representative: Ketelaars, Maarten F.J.M.  Nederlandsch Octrooibureau J.W. Frisolaan 13 2517 JS Den Haag 2517 JS Den Haag (NL)